Las coaliciones tarsianas como causa de dolor en el pie infantil: opciones terapéuticas / Tarsal coalitions as a cause of pain in the foot of children: Therapeutic options

Antecedentes y objetivo: La coalición tarsiana puede ser causa de dolor de medio-retropié en niños mayores. El objetivo es analizar los tipos de coalición tratados en nuestro centro hospitalario de 2010 a 2019 así como el tratamiento realizado. Material y método: Estudio observacional, descriptivo y retrospectivo de 18 pacientes con coalición tarsiana, 8 mujeres y 10 hombres, de 11,9±2,6 años de edad. Se recogieron datos epidemiológicos, hallazgos clínicos y de pruebas de imagen y tratamiento realizado. Resultados: Se revisaron 25 pies (38,8% bilaterales). El principal síntoma fue el dolor. Un 64% se asociaba a pie plano-valgo. El 52% se localizaba en la articulación calcáneo-escafoidea, y un 40% en la calcáneo-astragalina. El tratamiento fue conservador en un 44,4% de los casos y quirúrgico en el 56% (resección de la coalición). Se produjo un solo caso de recidiva. Los resultados fueron mayoritariamente excelentes o buenos (88%) tras un periodo medio de seguimiento de 4 años. Conclusiones: El tipo de coalición tarsiana diagnosticada con mayor frecuencia fue la localizada en la articulación calcáneo-escafoidea seguida de la calcáneo-astragalina, pero puede aparecer en cualquier articulación del pie. Casi la mitad respondieron bien al tratamiento conservador con resultados mayoritariamente buenos, pero el resto requirieron tratamiento quirúrgico por persistencia de la clínica, cuyos resultados fueron excelentes en todos los casos excepto en uno que sufrió una recidiva. En los casos de coaliciones calcáneo-astragalinas asociadas a valgo severo de retropié, la corrección de esta deformidad, asociada o no a la resección de la coalición, es recomendable.(AU)

Background and objective: The tarsal coalition can be a cause of mid-hindfoot pain in older children. The objective is to analyze the types of coalition treated in our hospital from 2010 to 2019 as well as the treatment carried out. Material and method: Observational, descriptive and retrospective study of 18 patients with tarsal coalition, 8 women and 10 men, aged 11.9±2.6 years. Epidemiological data, clinical findings and imaging tests, and treatment performed were collected. Results: Twenty-five feet (38.8% bilateral) were reviewed. The main symptom was pain. Sixty-four percent were associated with flat-valgus foot. Fifty-two percent were located in the calcaneal-scaphoid joint, and 40% in the calcaneal-talar joint. Treatment was conservative in 44.4% of cases and surgical in 56% (coalition resection). There was only one case of recurrence. The results were mostly excellent or good (88%) after a mean follow-up period of 4 years. Conclusions: The most frequently diagnosed type of tarsal coalition was that located in the calcaneal-scaphoid joint followed by the calcaneal-talar joint, but they can appear in any joint of the foot. Almost half responded well to conservative treatment with mostly good results, but the rest required surgical treatment due to persistence of the symptoms, the results of which were excellent in all cases except one who suffered a recurrence. In cases of calcaneal-talar coalitions associated with severe hindfoot valgus, correction of this deformity, associated or not with resection of the coalition, is recommended.(AU)

[Translated article] Tarsal coalitions as a cause of pain in the foot of children: Therapeutic options / Las coaliciones tarsianas como causa de dolor en el pie infantil: opciones terapéuticas

Antecedentes y objetivo: La coalición tarsiana puede ser causa de dolor de medio-retropié en niños mayores. El objetivo es analizar los tipos de coalición tratados en nuestro centro hospitalario de 2010 a 2019 así como el tratamiento realizado. Material y método: Estudio observacional, descriptivo y retrospectivo de 18 pacientes con coalición tarsiana, 8 mujeres y 10 hombres, de 11,9±2,6 años de edad. Se recogieron datos epidemiológicos, hallazgos clínicos y de pruebas de imagen y tratamiento realizado. Resultados: Se revisaron 25 pies (38,8% bilaterales). El principal síntoma fue el dolor. Un 64% se asociaba a pie plano-valgo. El 52% se localizaba en la articulación calcáneo-escafoidea, y un 40% en la calcáneo-astragalina. El tratamiento fue conservador en un 44,4% de los casos y quirúrgico en el 56% (resección de la coalición). Se produjo un solo caso de recidiva. Los resultados fueron mayoritariamente excelentes o buenos (88%) tras un periodo medio de seguimiento de 4 años. Conclusiones: El tipo de coalición tarsiana diagnosticada con mayor frecuencia fue la localizada en la articulación calcáneo-escafoidea seguida de la calcáneo-astragalina, pero puede aparecer en cualquier articulación del pie. Casi la mitad respondieron bien al tratamiento conservador con resultados mayoritariamente buenos, pero el resto requirieron tratamiento quirúrgico por persistencia de la clínica, cuyos resultados fueron excelentes en todos los casos excepto en uno que sufrió una recidiva. En los casos de coaliciones calcáneo-astragalinas asociadas a valgo severo de retropié, la corrección de esta deformidad, asociada o no a la resección de la coalición, es recomendable.(AU)

Background and objective: The tarsal coalition can be a cause of mid-hindfoot pain in older children. The objective is to analyze the types of coalition treated in our hospital from 2010 to 2019 as well as the treatment carried out. Material and method: Observational, descriptive and retrospective study of 18 patients with tarsal coalition, 8 women and 10 men, aged 11.9±2.6 years. Epidemiological data, clinical findings and imaging tests, and treatment performed were collected. Results: Twenty-five feet (38.8% bilateral) were reviewed. The main symptom was pain. Sixty-four percent were associated with flat-valgus foot. Fifty-two percent were located in the calcaneal-scaphoid joint, and 40% in the calcaneal-talar joint. Treatment was conservative in 44.4% of cases and surgical in 56% (coalition resection). There was only one case of recurrence. The results were mostly excellent or good (88%) after a mean follow-up period of 4 years. Conclusions: The most frequently diagnosed type of tarsal coalition was that located in the calcaneal-scaphoid joint followed by the calcaneal-talar joint, but they can appear in any joint of the foot. Almost half responded well to conservative treatment with mostly good results, but the rest required surgical treatment due to persistence of the symptoms, the results of which were excellent in all cases except one who suffered a recurrence. In cases of calcaneal-talar coalitions associated with severe hindfoot valgus, correction of this deformity, associated or not with resection of the coalition, is recommended.(AU)

[Translated article] Tarsal coalitions as a cause of pain in the foot of children: Therapeutic options.

BACKGROUND AND OBJECTIVE: The tarsal coalition can be a cause of mid-hindfoot pain in older children. The objective is to analyse the types of coalition treated in our hospital from 2010 to 2019 as well as the treatment carried out. MATERIAL AND METHOD: Observational, descriptive and retrospective study of 18 patients with tarsal coalition, 8 women and 10 men, aged 11.9±2.6 years. Epidemiological data, clinical findings and imaging tests, and treatment performed were collected. RESULTS: Twenty-five feet (38.8% bilateral) were reviewed. The main symptom was pain. Sixty-four percent were associated with flat-valgus foot. Fifty-two percent were located in the calcaneal-scaphoid joint, and 40% in the calcaneal-talar joint. Treatment was conservative in 44.4% of cases and surgical in 56% (coalition resection). There was only one case of recurrence. The results were mostly excellent or good (88%) after a mean follow-up period of 4 years. CONCLUSIONS: The most frequently diagnosed type of tarsal coalition was that located in the calcaneal-scaphoid joint followed by the calcaneal-talar joint, but they can appear in any joint of the foot. Almost half responded well to conservative treatment with mostly good results, but the rest required surgical treatment due to persistence of the symptoms, the results of which were excellent in all cases except one who suffered a recurrence. In cases of calcaneal-talar coalitions associated with severe hindfoot valgus, correction of this deformity, associated or not with resection of the coalition, is recommended.

Tarsal coalitions as a cause of pain in the foot of children: Therapeutic options. / Las coaliciones tarsianas como causa de dolor en el pie infantil: opciones terapéuticas.

BACKGROUND AND OBJECTIVE: The tarsal coalition can be a cause of mid-hindfoot pain in older children. The objective is to analyze the types of coalition treated in our hospital from 2010 to 2019 as well as the treatment carried out. MATERIAL AND METHOD: Observational, descriptive and retrospective study of 18 patients with tarsal coalition, 8 women and 10 men, aged 11.9±2.6 years. Epidemiological data, clinical findings and imaging tests, and treatment performed were collected. RESULTS: Twenty-five feet (38.8% bilateral) were reviewed. The main symptom was pain. Sixty-four percent were associated with flat-valgus foot. Fifty-two percent were located in the calcaneal-scaphoid joint, and 40% in the calcaneal-talar joint. Treatment was conservative in 44.4% of cases and surgical in 56% (coalition resection). There was only one case of recurrence. The results were mostly excellent or good (88%) after a mean follow-up period of 4 years. CONCLUSIONS: The most frequently diagnosed type of tarsal coalition was that located in the calcaneal-scaphoid joint followed by the calcaneal-talar joint, but they can appear in any joint of the foot. Almost half responded well to conservative treatment with mostly good results, but the rest required surgical treatment due to persistence of the symptoms, the results of which were excellent in all cases except one who suffered a recurrence. In cases of calcaneal-talar coalitions associated with severe hindfoot valgus, correction of this deformity, associated or not with resection of the coalition, is recommended.

Secondary metabolite biosynthetic diversity in the fungal family Hypoxylaceae and Xylaria hypoxylon.

To date little is known about the genetic background that drives the production and diversification of secondary metabolites in the Hypoxylaceae. With the recent availability of high-quality genome sequences for 13 representative species and one relative (Xylaria hypoxylon) we attempted to survey the diversity of biosynthetic pathways in these organisms to investigate their true potential as secondary metabolite producers. Manual search strategies based on the accumulated knowledge on biosynthesis in fungi enabled us to identify 783 biosynthetic pathways across 14 studied species, the majority of which were arranged in biosynthetic gene clusters (BGC). The similarity of BGCs was analysed with the BiG-SCAPE engine which organised the BGCs into 375 gene cluster families (GCF). Only ten GCFs were conserved across all of these fungi indicating that speciation is accompanied by changes in secondary metabolism. From the known compounds produced by the family members some can be directly correlated with identified BGCs which is highlighted herein by the azaphilone, dihydroxynaphthalene, tropolone, cytochalasan, terrequinone, terphenyl and brasilane pathways giving insights into the evolution and diversification of those compound classes. Vice versa, products of various BGCs can be predicted through homology analysis with known pathways from other fungi as shown for the identified ergot alkaloid, trigazaphilone, curvupallide, viridicatumtoxin and swainsonine BGCs. However, the majority of BGCs had no obvious links to known products from the Hypoxylaceae or other well-studied biosynthetic pathways from fungi. These findings highlight that the number of known compounds strongly underrepresents the biosynthetic potential in these fungi and that a tremendous number of unidentified secondary metabolites is still hidden. Moreover, with increasing numbers of genomes for further Hypoxylaceae species becoming available, the likelihood of revealing new biosynthetic pathways that encode new, potentially useful compounds will significantly improve. Reaching a better understanding of the biology of these producers, and further development of genetic methods for their manipulation, will be crucial to access their treasures.